| modified siRNA |
| GenePharma has all the internationally leading core technologies of siRNA chemical synthesis, especially the custom and chemically-modified siRNA oligo synthesis technology, the RNA monomer synthesis technology, |
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Chemically Modified siRNA Oligos |
GenePharma is an internationally leading company in RNA synthesis technology. We specialize in siRNA chemical synthesis, with a focus on custom and chemically modified siRNA oligomers, including fluorescent labeling and an array of nucleotide chemical modifications.
The most important challenge in RNA technology is the stability of the chemically synthesized siRNAs. The primary goal of GenePharma's chemical synthesis technologies is to create chemically modified RNA products that are highly stable and efficiently transfected with our special RNAi-mate transfection reagent so that you can achieve the best result for your particular experiment, especially in mammalian and human cell lines. Our chemically modified RNA oligomers are characterized by:
- Highly efficient transfection
- Highly efficient target gene knockdown
- High specificity for the target gene(s)
- High stability in serum and medium
- Minimized off-target gene knockdown or other side effects
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Table 1. Comparison of standard siRNA and chemically modified siRNA oligos.
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Standard unmodified siRNA |
Chemically modified siRNA |
siRNA degradation |
Easily degraded in transfected cells. |
Very stable and highly nuclease degradation-resistant in serum and transfected cells, without losing gene silencing capacity. |
Duration of gene silencing |
Relatively short time silencing effect, under normal circumstances approximately one week. |
Long time silencing effect, roughly twice that of standard siRNA. |
In vivo?suitability |
Due to its poor stability, usually not suitable for in vivo?experiments. However, it is effective in most?in vitro experiments. |
Due to its stability and longevity, the best choice for both in vitro?and in vivo studies. |
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Cat. No. |
Product information |
Quantity |
Purification |
Price |
Appropriate Times |
A02004 |
Chemically-modified siRNA |
5 OD |
HPLC |
$174 |
7?business days |
A02009 |
Chemically-modified siRNA |
10 OD |
HPLC |
$325 |
7?business days |
A02010 |
Chemically-modified siRNA |
25?OD |
HPLC |
$674 |
8?business days |
A02011 |
Chemically-modified siRNA |
50?OD |
HPLC |
$1250 |
10?business days |
A02012 |
Chemically-modified siRNA |
100 OD |
HPLC |
$2124 |
15?business days |
A02013 |
Chemically-modified siRNA |
250?OD |
HPLC |
$3999 |
20-30?business days |
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For technical questions, email support@genepharma.com. For questions related to order placement, email bd@genepharma.com. |
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