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High impact references (Large-scale high-throughput screens)

1. We finished the screening of functional genes regulating cell migration. The library we screened included miRNA mimics libraries (~900) (Zhang H. et al.,?Nature Communications,?2011, v2:554) and a human kinase siRNA library (~750) (under review).
2. We finished the siRNA screening of functional genes regulating autophagosome formation. The library we screened included a custom-based siRNA library (~300) (Rong Y. et al.,?Nature Cell Biology,?2012, v14(9):924-34). The screen using the whole human genome siRNA library (ABI, ~20,000) is undergoing.
3. We finished the screening of functional genes regulating cell invasion by use of multi-well plates. The library we screened included miRNA mimics libraries (~900) and human kinase siRNA library (~750).
4. We finished the screening of functional genes regulating cell apoptosis. The library we screened included miRNA mimics libraries (~900), the?human kinase siRNA library (~750) and esiRNAs (~100) (Wang Z. et al., PLoS, 2012).
5. We accomplished the screening of functional genes regulating mitochondrial fission and fusion. The library we screened includes miRNA mimics libraries (~900) (paper in preparation).
6. We are screening functional genes regulating NADH metabolism. The library includes the human kinase siRNA library (~750).
7. We are screening functional genes capable of generating synthetic lethal with a chemical. The library includes the human kinase siRNA library (~750) and phosphatase siRNA library (~300).
8. We are performing the screen in other cell assays, including insulin resistance, modulators in TGF-beta pathway, etc.

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