| RNAi Screening service |
| Using siRNA screening to select the genes which related cells life cycle has become a common tool for the research of gene chemistry and life science. The high throughput screening could analyze the functions of thousands genes, and promptly identify the relative genes,thus find new research targets |
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High impact references (Large-scale high-throughput screens)
- We finished the screening of functional genes regulating cell migration. The library we screened included miRNA mimics libraries (~900) (Zhang H. et al.,?Nature Communications,?2011, v2:554) and a human kinase siRNA library (~750) (under review).
- We finished the siRNA screening of functional genes regulating autophagosome formation. The library we screened included a custom-based siRNA library (~300) (Rong Y. et al.,?Nature Cell Biology,?2012, v14(9):924-34). The screen using the whole human genome siRNA library (ABI, ~20,000) is undergoing.
- We finished the screening of functional genes regulating cell invasion by use of multi-well plates. The library we screened included miRNA mimics libraries (~900) and human kinase siRNA library (~750).
- We finished the screening of functional genes regulating cell apoptosis. The library we screened included miRNA mimics libraries (~900), the?human kinase siRNA library (~750) and esiRNAs (~100) (Wang Z. et al., PLoS, 2012).
- We accomplished the screening of functional genes regulating mitochondrial fission and fusion. The library we screened includes miRNA mimics libraries (~900) (paper in preparation).
- We are screening functional genes regulating NADH metabolism. The library includes the human kinase siRNA library (~750).
- We are screening functional genes capable of generating synthetic lethal with a chemical. The library includes the human kinase siRNA library (~750) and phosphatase siRNA library (~300).
- We are performing the screen in other cell assays, including insulin resistance, modulators in TGF-beta pathway, etc.
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